Multiomics analysis of polyamine metabolism in colorectal cancer, highlighting the key role of extracellular putrescine in impairing CXCR6⁺CD8⁺ T cell anti-tumor activity.

ABSTRACT: The contribution of putrescine (PUT) metabolism to impaired tumor immunosurveillance in colorectal cancer (CRC) requires a thorough examination of its biosynthesis, catabolism, and transport during tumor development. This study found, unexpectedly, that a better prognosis was associated with higher expression of the PUT biosynthesis genes ODC1 and AGMAT, while elevated expression of biosynthesis inhibitors and transport genes predicted worse outcomes. Two independent cohorts were deconvoluted by integrating data from 517,191 cells across 221 samples from 131 subjects. Higher percentages of epithelial subpopulations with low PUT transport scores were linked to improved prognosis. In contrast, greater proportions of T/natural killer/ILC cells with low biosynthesis but relativel

SUBMITTER: Tan Z 

PROVIDER: S-EPMC12906710 | biostudies-literature | 2026

REPOSITORIES: biostudies-literature