Tailoring Liver Transplant Decisions: How Donor-Recipient Age Matching Influences Outcomes.

ABSTRACT:

Introduction

Donor age is a key determinant of liver transplant (LT) outcomes, but its impact varies across recipient age groups. Specific donor age thresholds associated with excess risk remain undefined.

Methods

Using data from the Scientific Registry of Transplant Recipients (2011-2021; follow-up through 2024), we analyzed first-time, single-organ LT recipients. Donors and recipients were stratified by age. Outcomes included patient, graft, and death-censored graft survival. Multivariable Cox regression models adjusted for liver disease severity, comorbidities, graft type, and transplant year were used to identify donor age thresholds associated with increased risk in each recipient age group.

Results

Among 70 078 recipients (median age, 57 years), mean donor age r

SUBMITTER: Abdullah A 

PROVIDER: S-EPMC12906856 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature