Changes by Era in Risk Factors and Outcomes Among Deceased Donor Kidney Transplant Recipients With Delayed Graft Function.

ABSTRACT:

Introduction

There are no effective therapeutic agents for preventing or treating delayed graft function (DGF) among deceased donor kidney transplant recipients (DDKTRs). Donor and recipient factors are important to predicting DGF and associated outcomes, which we hypothesize differed over time.

Methods

DDKTRs were stratified by transplant year into four eras-E1 (2000-2005), E2 (2006-2011), E3 (2012-2017), and E4 (2018-2021). We analyzed risk factors for DGF, along with one-year uncensored graft failure (UCGF), death-censored graft failure (DCGF), death with a functioning graft (DWFG), and acute rejection (AR) by era.

Results

A total of 3085 DDKTRs were included (E1: 804, E2: 882, E3: 909, E4: 490). The proportion of patients with DGF differed significantly by era. Du

SUBMITTER: Ylagan CC 

PROVIDER: S-EPMC12906863 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature