Genetic relations between type 1 diabetes, coronary artery disease and leukocyte counts.

ABSTRACT:

Aims/hypothesis

Type 1 diabetes is associated with excess coronary artery disease (CAD) risk even when known cardiovascular risk factors are accounted for. Genetic perturbation of haematopoiesis that alters leukocyte production is a novel independent modifier of CAD risk. We examined whether there are shared genetic determinants and causal relationships between type 1 diabetes, CAD and leukocyte counts.

Methods

Genome-wide association study summary statistics were used to perform pairwise linkage disequilibrium score regression and heritability estimation from summary statistics (ρ-HESS) to respectively estimate the genome-wide and local genetic correlations, and two-sample Mendelian randomisation to estimate the causal relationships between leukocyte counts (335,855 healthy

SUBMITTER: Adebekun J 

PROVIDER: S-EPMC12906866 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature