FCGBP Promotes Glioma Growth by Regulating JAK2/STAT3/c-Myc Pathway.

ABSTRACT:

Background

FCGBP has been implicated in the development of a variety of tumors, but its exact role in glioma progression remains unclear.

Methods

This study utilized qRT-PCR, Western blotting (WB), immunohistochemistry (IHC), and other techniques to assess FCGBP expression in glioma tissues. Additionally, various functional experiments were conducted to investigate its role in glioma progression. Animal models were employed to further elucidate the function of FCGBP, with a particular focus on its impact on the Janus Kinase 2/Signal Transducer and Activator of Transcription 3 (JAK2/STAT3) signaling pathway.

Results

The research findings indicated that FCGBP is significantly overexpressed in glioma and is closely associated with higher tumor grades and unfavorable clin

SUBMITTER: Zheng J 

PROVIDER: S-EPMC12906970 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature