Efficacy and long-term effects of intermittent theta burst stimulation on negative symptoms in schizophrenia: a systematic review and meta-analysis.

ABSTRACT: This study aims to investigate the clinical efficacy and long-term benefits of intermittent theta burst stimulation (iTBS) in alleviating negative symptoms in patients with schizophrenia. Two authors independently identified eligible studies from the Medical Literature Analysis and Retrieval System Online, Cochrane Library, Web of Science, and Excerpta Medica Database databases up to October 21, 2024. Our meta-analysis was conducted using Review Manager 5.3 and Stata 14 software. Seventeen randomized controlled trials with a total of 764 participants were included in the meta-analysis. iTBS demonstrated greater efficacy in alleviating negative symptoms immediately after treatment (standardized mean difference = -0.55, 95% confidence interval: -1.00 to -0.10). Improved outcomes were associa

SUBMITTER: Tong S 

PROVIDER: S-EPMC12906989 | biostudies-literature | 2026

REPOSITORIES: biostudies-literature