Implementing Kidney Disease: Improving Global Outcomes 2024 Through Laboratory-Estimated GFR Across Ages.

ABSTRACT:

Introduction

Chronic kidney disease (CKD) represents a major public health issue, with early detection depending on accurate estimation of glomerular filtration rate (GFR). The 2024 Kidney Disease: Improving Global Outcomes (KDIGO) guidelines recommend age-adapted equations, whereas the 2009 CKD Epidemiology Collaboration (CKD-EPI) equation remains widely used in Europe despite its inapplicability in children and uncertain performance in young adults and the elderly. The objectives of this study were to compare the European Kidney Function Consortium (EKFC) and 2009 CKD-EPI equations for estimated GFR (eGFR)-based CKD staging in a general population (PCrAGE substudy), and to evaluate their performance against measured GFR (mGFR) in a reference cohort (mGFR substudy).

Methods

SUBMITTER: De Mul A 

PROVIDER: S-EPMC12907000 | biostudies-literature | 2026 Mar

REPOSITORIES: biostudies-literature