Association of High-Density Lipoprotein Cholesterol with Macular Structure in Nonglaucomatous Individuals.

ABSTRACT:

Purpose

To investigate the association between serum high-density lipoprotein cholesterol (HDL-C) levels and ganglion cell complex (GCC) thickness in a nonglaucomatous Japanese population.

Design

A retrospective cross-sectional observational study.

Participants

We included 588 nonglaucomatous Japanese adults who underwent comprehensive ophthalmic and systemic health screening.

Methods

Participants underwent OCT imaging, anthropometric measurements, including brachial-ankle pulse wave velocity, spirometry, and hematologic profiling. Multivariable linear regression models were used to assess the association between HDL-C levels and GCC thickness. Covariates were selected using a stepwise variable selection procedure, with the final model including age and axial l

SUBMITTER: Inooka T 

PROVIDER: S-EPMC12907079 | biostudies-literature | 2026 Mar

REPOSITORIES: biostudies-literature