Phenome-Wide Associations of Polygenic Scores for Schizophrenia and Major Depression in 100,000 Chinese Adults.

ABSTRACT:

Background

China faces significant mental health challenges, with unique associations between mental disorders and other traits observed in its population.

Methods

Based on summary statistics of existing genome-wide association studies in East Asian ancestry (EAS) and European ancestry (EUR) populations, we tested the associations of polygenic scores (PGSs) for schizophrenia (SCZ) and major depression (MD) with 254 phenotypes in 100,640 Chinese adults. We also conducted genetic correlation and Mendelian randomization analyses to assess the consistency of these associations across ancestries and infer causality.

Results

The PGSs predicted SCZ (R ² = 2.63%-3.07%) and MD (R ² = 0.21%-0.71%) and were associated with various sociodemogra

SUBMITTER: Wang B 

PROVIDER: S-EPMC12907099 | biostudies-literature | 2026 Mar

REPOSITORIES: biostudies-literature