<i>Viscum album</i> L. mother tinctures modulate Na⁺/K⁺ ATPase activity and expression, and promote endothelium-dependent vasodilation via SK channel and nitric oxide signalling.

ABSTRACT:

Introduction

Ethanolic extracts of Viscum album L. (European mistletoe), known as mother tinctures (VAMTs), have been used in traditional medicine to treat hypertension and cardiovascular diseases. However, the underlying biological mechanisms remain poorly characterized.

Methods

This study investigated the cytotoxic, and cardiovascular effects of ten VAMTs prepared from fresh plants harvested in summer and winter. The extracts were derived from three subspecies (V. album subsp. album, abietis, and austriacum) growing five distinct host tree species. Cytotoxicity and oxidative stress were assessed in vitro, while the effects on Na⁺/K⁺-ATPase activity and expression were evaluated in porcine renal proximal tubular cells. Additionally

SUBMITTER: Duarte RDSP 

PROVIDER: S-EPMC12907139 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature