From plaque to event: coronary plaque burden and morphology in predicting adverse cardiovascular outcomes.

ABSTRACT:

Aims

This study aimed to identify the association of plaque burden and morphological features, such as burden, length, and composition, with major adverse cardiovascular events (MACE) in populations with very high cardiovascular risk using coronary computed tomography angiography (CTA).

Methods and results

A retrospective cohort study was performed in Lithuania among stable symptomatic patients who underwent coronary CTA. All plaques were manually inspected using plaque analysis software. The study included 772 patients. The mean age was 59.6 ± 9.9 years in men and 65.2 ± 8.7 years in women (p < 0.001). Women exhibited relatively greater proportions of densely calcified plaque volume, whereas men demonstrated significantly higher proportions of fibrous, fibrofatty, an

SUBMITTER: Dvinelis E 

PROVIDER: S-EPMC12907141 | biostudies-literature | 2026

REPOSITORIES: biostudies-literature