Latent profiles of childhood trauma in bipolar disorder: associations with objective and subjective cognitive functioning and quality of life.

ABSTRACT:

Introduction

Childhood trauma is associated with a more severe clinical course in bipolar disorders; however, the latent profiles of childhood trauma and their differential impacts on cognitive functioning and quality of life remain underexplored.

Methods

Using latent profiles analysis, 275 bipolar patients were categorized into distinct trauma profiles based on Childhood Trauma Questionnaire scores. The characteristics of sociodemographic, clinical, pharmacological and biochemical variables, as well as objective and subjective cognitive functioning, and quality of life, were compared across profiles and with 63 healthy controls.

Results

Three distinct profiles emerged: high trauma (HT, 14.55%), high neglect (HN, 30.18%) and low trauma (LT, 55.27%

SUBMITTER: Ma R 

PROVIDER: S-EPMC12907306 | biostudies-literature | 2026

REPOSITORIES: biostudies-literature