Exploring biomechanical differences between brain-first and body-first Parkinson's disease subtypes using shear wave elastography: a pilot cross-sectional study.

ABSTRACT:

Objective

This exploratory study aimed to investigate whether ultrasound shear wave elastography (SWE) could quantify rigidity in Parkinson's disease (PD) and assess potential biomechanical differences between the brain-first and body-first subtypes.

Methods

Shear wave elastography was used to measure the Young's modulus (YM) and shear wave velocity (SWV) of the biceps brachii in 70 healthy controls (HCs) and 102 patients with PD (40 classified as body-first, 62 classified as brain-first based on RBDSQ criteria). Group comparisons were conducted using t-tests or ANOVA, correlations were assessed via Pearson or Spearman tests, and diagnostic performance was evaluated using receiver operating characteristic (ROC) curve analysis.

Results

Young's modulus and SWV va

SUBMITTER: Dong S 

PROVIDER: S-EPMC12907343 | biostudies-literature | 2026

REPOSITORIES: biostudies-literature