Arbor-TVB: a novel multi-scale co-simulation framework with a case study on neural-level seizure generation and whole-brain propagation.

ABSTRACT: Computational neuroscience has traditionally focused on isolated scales, limiting understanding of brain function across multiple levels. While microscopic models capture biophysical details of neurons, macroscopic models describe large-scale network dynamics. Integrating these scales, however, remains a significant challenge. In this study, we present a novel co-simulation framework that bridges these levels by integrating the neural simulator Arbor with The Virtual Brain (TVB) platform. Arbor enables detailed simulations from single-compartment neurons to populations of such cells, while TVB models whole-brain dynamics based on anatomical features and the mean neural activity of a brain region. By linking these simulators for the first time, we provide an example of how to model and inve

SUBMITTER: Hater T 

PROVIDER: S-EPMC12907379 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature