Garcinone C inhibits pseudorabies virus replication through EGF/PI3K/Akt axis.

ABSTRACT:

Introduction

Pseudorabies virus (PRV), a significant pathogen of swine, causes substantial economic losses, and even poses an emergent public health concern due to its zoonotic potential. The continuous evolution of PRV has undermined the effectiveness of current vaccines and antiviral drugs. Consequently, there is an urgent need to develop novel strategies to curb its spread.

Methods

The inhibitory effect of garcinone C on PRV replication was assessed in vivo and in vitro. To determine the stage of antiviral action, treatments were administered at different time points: pre-treatment, co-treatment, and post-infection. RNA sequencing was performed, and differentially expressed genes (DEGs) were identified.

Results

In the study, we found that garcinone C

SUBMITTER: Lv C 

PROVIDER: S-EPMC12907380 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature