Cerebellar Tissue Properties Alterations in Fibromyalgia: A T1w/T2w Ratio Study.

ABSTRACT: Fibromyalgia is associated with elevated levels of comorbid anxiety and depression, together impacting brain morphology possibly reflecting common underlying biological processes. The present study aims to determine the difference in regional myelination in females with fibromyalgia compared with females who do not experience chronic pain and to determine the role of the severity of comorbid anxiety and depressive symptoms experienced to mediate this difference in brain myelination. Thirty-three females with and 33 females without (controls) fibromyalgia were included, for which the severity of depressive and anxiety symptoms was recorded using the Hamilton Anxiety/Depression Rating scales (HAMA/HAMD). Whole-brain three-dimensional T1-weighted (T1w) and T2-weighted (T2w) magnetic resonance

SUBMITTER: Quide Y 

PROVIDER: S-EPMC12907518 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature