Loss of Myonuclei and Transcriptional Activity During Diaphragm Atrophy in Critically Ill Patients.

ABSTRACT:

Background

Diaphragm weakness frequently develops in critically ill patients and is explained by a combination of atrophy and myofiber dysfunction. Myofibers are large syncytial cells maintained by a population of myonuclei, which provide gene transcripts to a finite fiber volume, termed the myonuclear domain. Myonuclear number is a determinant of transcriptional capacity and therefore critical for diaphragm and peripheral muscle regeneration after critical illness. Changes in myonuclear number in myofibers undergoing atrophy have not been investigated in mechanically ventilated ICU patients, but they are of potential clinical importance. Our objective was to investigate if and how myonuclear number changes in the diaphragm of mechanically ventilated ICU patients and whether change

SUBMITTER: Claassen WJ 

PROVIDER: S-EPMC12907519 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature