Genetically Predicted Homocysteine Levels and B Vitamins on Sarcopenia-Related Traits: Insights From an Observational and Mendelian Randomization Analysis.

ABSTRACT: Sarcopenia is a significant public health concern that adversely affects the health and quality of life of older adults. The causal and longitudinal relationships between homocysteine (Hcy), B vitamins, and sarcopenia remain unclear. This study integrated genetic evidence with clinical cohort data to investigate these associations using a two-stage design. First, we performed a two-sample Mendelian randomization (MR) analysis using summary data from large-scale genome-wide association studies (GWAS) of European ancestry. We examined the potential causal effects of Hcy, Vit B₆, folate, and Vit B₁₂ on sarcopenia-related phenotypes, including appendicular lean mass (ALM), grip strength, and walking pace, using the inverse-variance weighted (IVW) method as the primary ana

SUBMITTER: Yang C 

PROVIDER: S-EPMC12907574 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature