Risk of metachronous upper tract urothelial carcinoma following non-muscle-invasive bladder cancer.

ABSTRACT:

Objective

To determine the risk and timing of metachronous upper tract urothelial carcinoma (UTUC) after non-muscle-invasive bladder cancer (NMIBC).

Patients and methods

In this multi-institutional retrospective cohort study involving academic and community hospitals, clinicopathological data were collected from patients with NMIBC treated between 2005 and 2022. Patients with prior or synchronous UTUC at NMIBC diagnosis were excluded. The primary outcome was time to metachronous UTUC, confirmed on pathology or upper tract imaging. Secondary objectives included determining the cumulative incidence of UTUC stratified by the European Association of Urology risk groups and UTUC risk factors identified using Fine and Gray regression, with all-cause mortality as a competing risk.<

SUBMITTER: Pace KJC 

PROVIDER: S-EPMC12907774 | biostudies-literature | 2026 Mar

REPOSITORIES: biostudies-literature