Exploring the role of lipid metabolism genes in gastric cancer prognosis and tumor immune microenvironment.

ABSTRACT: BackgroundGastric cancer remains a major global health challenge due to its high mortality rate and complex pathophysiological mechanisms. Emerging evidence highlights that dysregulated lipid metabolism contributes to gastric cancer progression and prognosis, but the associations between lipid metabolism-associated genes, gastric cancer patient survival, and tumor immune microenvironment remodeling are not fully elucidated.MethodsWe analyzed publicly available omics and clinical data, including RNA sequencing data from 371 gastric cancer samples in The Cancer Genome Atlas database and 433 gastric cancer samples in the Gene Expression Omnibus database. We first curated the top 100 lipid metabolism-associated genes based on relevance scores. Then, univariate Cox regression was used to identi

SUBMITTER: Xiao Y 

PROVIDER: S-EPMC12907803 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature