A Stress-Neuroendocrine-Myeloid Inflammation Axis Is Associated with the Progression of Meniere's Disease.

ABSTRACT:

Background

Ménière disease (MD) is a chronic inner ear disorder of unknown etiology. Although an immune-inflammatory link is suspected, the upstream triggers and cellular mechanisms connecting psychosocial stress to inner ear pathology remain poorly defined. This study aimed to investigate the role of stress-related, myeloid cell-derived inflammation in the progression of MD.

Methods

This multi-cohort study involved 384 MD patients (62.5% female); and 138 healthy controls (HCs) (46.4% female). Perceived stress was evaluated in 110 MD patients and 65 HCs. Transcriptional profiles were characterized using RNA sequencing on peripheral whole blood (4 MD, 6 HC) and on sorted CD11b + myeloid cells versus CD11b-non-myeloid cells (8 MD, 6 HC). In a larger cross-sectional cohort (239

SUBMITTER: Li X 

PROVIDER: S-EPMC12907869 | biostudies-literature | 2026 Mar

REPOSITORIES: biostudies-literature