Voclosporin shows protective effect and intestinal barrier enforcement in experimental colitis.

ABSTRACT: The treatment of inflammatory bowel disease (IBD) is still challenging. Therefore, it is crucial not only to develop new drugs specifically targeting IBD but also to evaluate the application and efficacy of already established pharmaceuticals used for related disorders. A promising new candidate is Voclosporin (Voc), a recently approved drug for lupus nephritis. In this study, we aimed to further elucidate the efficiency and the molecular mechanism of action of Voclosporin in comparison with its analogon cyclosporine A (CsA). Using an experimental colitis model and human PBMCs, we performed a comprehensive analysis including mini-endoscopy, histopathology, multi-photon endomicroscopy (MPEM), immunofluorescence staining, flow cytometry, and cytokine secretion profiling of murine lamina prop

SUBMITTER: Gabel M 

PROVIDER: S-EPMC12908035 | biostudies-literature | 2026

REPOSITORIES: biostudies-literature