IR Spectroscopy and Linear Support Vector Machine Analysis of Colorectal Liver Metastasis.

ABSTRACT: The Colorectal Liver Metastasis (CLM) library contains 756,096 full range Fourier transform infrared (FTIR) microscope imaging spectra of 14 frozen tissue sections from 7 different consenting patients with liver metastasis of colorectal origin. A subset of 30 windows was defined in predominant tumor or nontumor regions for the training or testing of linear support vector machine (SVM) models. Since the number of consenting patients was small, the primary purpose of this work was to establish a physical chemistry perspective on the infrared (IR) spectroscopy of metastatic liver cancer using the large number of available spectra. The linear SVM model was trained with a Leave-One-Case-Out strategy to avoid case leakage, minimize overtraining, and offer simple feature selection. The primary re

SUBMITTER: Coe JV 

PROVIDER: S-EPMC12908113 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature