MBOAT1 Promotes Glioma Progression Through Enhancing Ferroptosis Resistance and Immunosuppressive Microenvironment.

ABSTRACT:

Background

Emerging evidence indicates that ferroptosis characterized by lipid peroxidation is becoming a promising therapeutic strategy in glioma. However, the role of the MBOAT family, key regulators of membrane phospholipids remodeling in ferroptosis, remains unexplored in glioma.

Methods

We systematically analyzed the expression and clinical significance of MBOAT1 in glioma using TCGA, CGGA, GEO, and GTEx databases. Functional mechanisms were investigated through enrichment, single-cell RNA sequencing, and immune infiltration analyses. We experimentally validated the oncogenic role of MBOAT1 in GBM through both in vivo and in vitro experiments.

Results

MBOAT1 expression was elevated in glioma and correlated with increased grades and poor patient prognosis. Cox reg

SUBMITTER: Fan J 

PROVIDER: S-EPMC12908195 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature