Triazine-Trione Thermosets with High Processability for Scaffold Applications in Bone Tissue Engineering.

ABSTRACT: Despite advances in scaffold development, many current biomaterials suffer from limited processability or poor biological performance. To address this, we previously introduced two novel triazine-trione (TATO)-based thermosets, T-ene and T-yne, as candidates for tissue engineering applications. In the present study, we aim to comprehensively evaluate the initial cellular response of bone marrow mesenchymal stem/stromal cells (BMSC) on TATO materials and their osteogenic potential, with a particular focus on their suitability for bone tissue engineering applications. Both T-ene and T-yne demonstrated biocompatibility comparable to polycaprolactone (PCL), as assessed by in vitro cell behavior and the chorioallantoic membrane (CAM) assay. Transcriptomic profiling via RNA sequencing of BMSC cu

SUBMITTER: Johansen A 

PROVIDER: S-EPMC12908209 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature