Runs of homozygosity in Italian Holstein bulls: a permutation approach and time-based mapping of the genomic regions potentially under selection.

ABSTRACT:

Background

Runs of homozygosity (ROH) occurrence in animal genomes may result from a high level of relatedness within the population or from positive selection. ROH investigation enables the assessment of the degree of individual autozygosity at the genome-wide level, providing insights into genetic background and development history of a population. In this context, the main objectives of this study were to: 1) develop a method based on permutation tests for detecting single nucleotide polymorphisms (SNP) significantly included in ROH genomic regions of Italian Holstein bulls; 2) identify candidate genes close to the SNP frequently positioned within ROH; 3) investigate the effects of genetic selection on ROH distribution and ROH islands; and 4) assess potential associations betwee

SUBMITTER: Falchi L 

PROVIDER: S-EPMC12908255 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature