Normalized creatinine-to-cystatin C ratio and cardiovascular disease risk in populations with cardiovascular-kidney-metabolic syndrome stages 0-3: findings from a national and prospective cohort study.

ABSTRACT:

Background

The normalized creatinine-to-cystatin C ratio (NCCR) has been identified as a viable metric for assessing skeletal muscle mass and diabetes risk. However, the relationship between NCCR and cardiovascular disease (CVD) remains insufficiently understood. This study aims to clarify this association within a national, longitudinal, and prospective cohort.

Methods

Participants were selected from the China Health and Retirement Longitudinal Study to form the study cohort. Baseline NCCR was designated as the exposure variable, while the primary outcome was the incidence of newly diagnosed CVD. Participants were divided into four groups (Q1-Q4) based on the quartiles of baseline NCCR. The risk of CVD across different NCCR groups was assessed using Cox proportional hazards

SUBMITTER: Chen D 

PROVIDER: S-EPMC12908278 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature