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Circ_0008219 regulates proliferation and apoptosis in goat granulosa cells via a feedback loop with the transcription factor YY1.


ABSTRACT:

SUBMITTER: Tao H 

PROVIDER: S-EPMC12908286 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature

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Circ_0008219 regulates proliferation and apoptosis in goat granulosa cells via a feedback loop with the transcription factor YY1.

Tao Hu H   Jiang Fan F   Zhang Nian N   Shuai Yi Y   Zhao Hua H   Yang Juan J   Zhang Feng F   Shangguan Aishao A   Xiong Qi Q  

BMC genomics 20260121 1


BACKGROUND: Circular RNAs (circRNAs) are a class of competitive endogenous RNAs (ceRNAs) widely found in animals, they can directly or indirectly affect the proliferation and apoptosis of granulosa cells (GCs) by regulating microRNA (miRNA) pathways. Preliminary research findings indicate that circ_0008219 is differentially expressed in pre-ovulatory follicles between Boer goats and Macheng black goats, suggesting its potential critical role in goat ovulation. As a potential target, its specific  ...[more]

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