Identification of the E3 ligase TRIM21 as a crucial regulator of STAT1 in metabolic dysfunction-associated steatohepatitis.

ABSTRACT:

Background and aims

Metabolic associated fatty liver disease (MAFLD) is closely associated with metabolic disorders, including central obesity, dyslipidaemia, hypertension, hyperglycaemia and persistent abnormalities of liver function tests. Metabolic dysfunction-associated steatohepatitis (MASH) is a progressive form of MAFLD, characterized by chronic inflammation and accumulation of fat in liver tissue. Currently, no pharmacological interventions specifically tailored for MASH are approved. Signal transducer and activator of transcription 1 (STAT1) is the key transcription factor of the JAK-STAT signaling pathway, participating in physiological and pathological processes such as immune regulation, inflammatory response, antiviral defense, cell proliferation and apoptosis, and pla

SUBMITTER: Chen XX 

PROVIDER: S-EPMC12908364 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature