Astragalus polysaccharide improves canine sperm quality after chilled storage via promoting AMPK phosphorylation.

ABSTRACT:

Background

In vitro semen preservation is a crucial technique for conserving genetic material from male dogs. However, during the storage, oxidative damage can compromise key sperm structures, resulting in the decline of sperm viability, affecting their recognition of oocytes, and even causing sperm death. Therefore, the addition of exogenous antioxidants to alleviate the oxidative damage to sperm has become an important strategy to improve the effect of sperm storage in vitro. Astragalus polysaccharide (APS) is a kind of water soluble heteropolysaccharide with high-efficiency antioxidant activity, but its effect and mechanism in the preservation of canine semen remain to be studied. Thus, the present was designed to investigate the effects of APS on canine sperm after chilled stor

SUBMITTER: Huang X 

PROVIDER: S-EPMC12908368 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature