Alterations in functional connectivity of the anterior cingulate cortex associated with different levels of tau and amyloid-<i>β</i> deposition in patients with mild cognitive impairment.

ABSTRACT:

Background

Three subgroups of mild cognitive impairment (MCI) may be identified based on the deposition of Aβ and tau proteins: A-T-, A + T+, and A + T-. The key hub for information processing and control, the anterior cingulate cortex (ACC), is essential for both healthy aging and MCI. The objective of this research is to systematically investigate changes in the functional connectivity (FC) of ACC subregions across different MCI subtypes.

Methods

Overall, 54 A-T- patients, 28 A + T- patients, and 52 A + T + patients underwent FC analysis of ACC subregions. Correlation analyses were conducted to explore the relationship among pathological biomarkers, cognitive function, and FC changes in ACC subnetworks. The diagnostic utility of ACC-cortical FC in differentiating MCI subty

SUBMITTER: Qi W 

PROVIDER: S-EPMC12908466 | biostudies-literature | 2026

REPOSITORIES: biostudies-literature