Impact of corticosteroid administration on contrast-enhancing volume and diffusion MRI in treatment naive glioblastoma.

ABSTRACT:

Background

Corticosteroids impact the radiographic interpretation of glioblastoma, including artificial reduction in the contrast-enhancing tumor volume and intensity (i.e., a "pseudoresponse") and in the apparent diffusion coefficient (ADC). This study aimed to estimate the influence of corticosteroids on these measurements in treatment naïve glioblastoma before surgery.

Methods

Fifty-seven pairs of MRI scans from 54 patients with presurgical treatment-naïve glioblastoma were retrospectively grouped as increased (n = 29, all corticosteroid-free at baseline), stable (n = 25), or decreased (n = 3) corticosteroid dose between scans (median interval: 15 days). Tumor size and ADC changes between timepoints were compared between lesions with increased and stable corticosteroids.

SUBMITTER: Sanvito F 

PROVIDER: S-EPMC12908483 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature