Glioportal: a comprehensive transcriptomic resource unveiling ligand-mediated mesenchymal transition in glioblastoma.

ABSTRACT:

Background

Multi-omics profiling of glioblastoma (GBM) has unraveled two aspects fundamental to its aggressiveness and lethality that is molecular heterogeneity inherent to the tumor and cellular plasticity modulated by the microenvironment. Yet, empirical validation to identify causal factors for these complex mechanisms is rather scarce. Here, we report our endeavor in establishing Glioportal, a GBM tumor biobank with derivative preclinical models and molecular information that we leverage for basic and translational research on precision therapies.

Methods

Bulk transcriptome and single-cell-based deconvolution analyses highlighted key features of distinct GBM subtypes and ligand-receptor pairs predicted to regulate malignant cell state plasticity. Synthetic genetic tracin

SUBMITTER: Pang QY 

PROVIDER: S-EPMC12908495 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature