Activation of donor-derived eosinophils during static storage contributes to primary graft dysfunction after lung transplantation.

ABSTRACT: Ischemia-reperfusion injury (IRI) contributes to deleterious outcomes after lung transplantation. Although we have shown a unique protective role for eosinophils in both establishing and maintaining lung allograft tolerance, their role in IRI remains unclear. Based on previous research demonstrating a protective role for eosinophils in liver IRI, we hypothesized, they might play a similar function in the lung. Here, we show that donor-, but not recipient-derived, eosinophils worsen injury of syngeneic and allogeneic lung grafts rather than protect from it. Eosinophils in lungs stored in a low potassium dextran-based extracellular preservation solution become activated, degranulate, and die during rewarming. This damage correlates with decreased oxygenation and increased tissue injury upon

SUBMITTER: Taheri M 

PROVIDER: S-EPMC12908519 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature