The relationship between arthritis and mild cognitive impairment in different obese metabolic heterogeneity populations-the mediating role of depression.

ABSTRACT:

Objective

The purpose of this study is to investigate whether depression may mediate the association between arthritis and mild cognitive impairment (MCI) in diverse BMI-based obese populations with multi-parameter metabolic signatures including insulin resistance, inflammatory markers, and lipid metabolism indices.

Methods

The relationships between arthritis, MCI, and depression were investigated in a large-scale study that used logistic regression, subgroup analyses, and mediation analyses. The participants in the study came from obese individuals classified into distinct metabolic obesity phenotypes based on insulin resistance, inflammatory markers, and lipid metabolism.

Results

Arthritis is positively correlated with MCI (OR = 1.86, 95% CI = 1.60-2.17, p < 

SUBMITTER: Li C 

PROVIDER: S-EPMC12908586 | biostudies-literature | 2026

REPOSITORIES: biostudies-literature