Inflammatory cytokines secreted from senescent periodontal ligament cells influence the osteocyte network in alveolar bone.

ABSTRACT: The rate of orthodontic tooth movement slows with age, likely due to changes in alveolar bone remodeling. However, the underlying mechanisms remain poorly understood. Osteocytes (OCys), which form the lacunar-canalicular network (LCN), play a key role in bone metabolism; however, the effects of aging on the alveolar LCN are still unclear. This study aimed to clarify age-related alterations in the LCN of alveolar bone and their underlying mechanisms. The LCN was visualized using Ploton silver staining, revealing a significant reduction in 16-mo-old C57BL/6J mice compared to 2-mo-old mice. The number of OCys, as well as the number and length of canaliculi per OCy, decreased significantly with age. These reductions were consistent in both sexes. Periodontal ligament cells (PDLCs) from aged mi

SUBMITTER: Yamashita A 

PROVIDER: S-EPMC12908679 | biostudies-literature | 2026 Mar

REPOSITORIES: biostudies-literature