Aquaporin 5 transfer via MDA-MB-231 cell extracellular vesicles increases recipient endothelial cell invasion.

ABSTRACT: Aquaporin 5 (AQP5), a water channel protein, is a known promoter of cancer metastasis, primarily through its role in enhancing cancer cell motility and invasion. While this function has been studied extensively in cancer cells themselves, the contribution of AQP5 to the behavior of other cells in the tumor microenvironment, particularly endothelial cells, remains less understood. Prior studies have linked secreted signals from cancer cells with higher AQP5 expression to increased endothelial angiogenic capacity, a key driver of metastasis. Separately, metastasis-associated proteins have been shown to transfer from cancer to endothelial cells via extracellular vesicles (EVs), promoting angiogenesis. In this study, we investigated whether AQP5-containing EVs influence endothelial cell behavi

SUBMITTER: Smith IM 

PROVIDER: S-EPMC12908701 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature