Exploring the Genetic Association and Genetic Architecture of Iridocyclitis and Extraocular Autoimmune Diseases.

ABSTRACT:

Purpose

Our objective was to explore the shared genetic risks between iridocyclitis and extraocular autoimmune diseases, as well as refine the regulatory network of genetic and environmental mechanisms by incorporating endocrine-disrupting chemicals (EDCs).

Methods

Using summary statistics reporting genome-wide association study findings within European ancestry, we first investigated the genetic associations between iridocyclitis and extraocular autoimmune diseases. We then performed causal inference using Mendelian randomization (MR). By integrating genetic and causal associations, we explored the comorbid genetic structure and shared risk genes between iridocyclitis and ulcerative colitis (UC) through cross-trait analysis and a transcriptome-wide association study (TWAS).

SUBMITTER: Yuan F 

PROVIDER: S-EPMC12908726 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature