Single-cell transcriptomics reveals the landscape of immune phenotypes in pituitary neuroendocrine tumors.

ABSTRACT:

Background

Immune cells critically influence pituitary neuroendocrine tumor (PitNET) progression and therapeutic responses. However, their composition and functional dynamics remain unclear. This study aimed to delineate the immune heterogeneity and intercellular communication networks within PitNETs.

Methods

This study conducted single-cell RNA sequencing (scRNA-seq) on 22 fresh PitNET samples obtained from surgical patients at Beijing Tiantan Hospital between September 2023 and January 2024, with classification based on the expression of key transcription factors: pituitary-specific transcription factor 1 (PIT1), steroidogenic factor 1 (SF1), and T-box transcription factor 19 (TPIT). Following cell type identification, cell-cell communication analysis revealed specific int

SUBMITTER: Zhang Z 

PROVIDER: S-EPMC12908783 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature