Triglycerides play a crucial role in the pathway from depression to cardiomyopathy: A mediation Mendelian randomization study.

ABSTRACT: The causal relationships among depression, hypertriglyceridemia, and cardiomyopathy remain undefined. Cardiomyopathy encompasses both ischemic heart disease (IHD) and dilated cardiomyopathy (DCM). Inverse variance weighted random-effect, inverse variance weighted fixed-effect, maximum likelihood estimation, MR-Egger, weighted median, and penalized weighted median were employed to evaluate the causal relationship between exposure and outcome. Stepwise testing and multivariable Mendelian randomization analyses were employed in the mediation analysis. The onset of depression precipitates an increase in triglyceride levels, which in turn escalates the risk of developing DCM. The onset of depression not only directly escalates the risk of developing IHD but also indirectly amplifies this risk b

SUBMITTER: Sheng B 

PROVIDER: S-EPMC12908811 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature