P300 upregulates I kur in atrial cardiomyocytes through activating NLRP3 inflammasome in hypertension.

ABSTRACT:

Background

The nucleotide-binding oligomerization domain [NOD-], leucine-rich repeats [LRR-], and Pyrin domain-containing protein 3 (NLRP3) inflammasome plays an essential role in hypertension-related atrial fibrillation (AF). p300 is involved in cardiovascular inflammation. In this study, we aimed to investigate the role of p300 in NLRP3 inflammasome activation and its subsequent impact on the I kur current in angiotensin II (Ang II)-induced HL-1 cells and Ang II-infused mice.

Methods

Expression levels of p300, Kv1.5, and NLRP3 in left atrial appendage (LAA) tissues from AF and participants with sinus rhythm (SR) were detected by Western blot. A hypertension mouse model was established in p300 knockout ( p300 -KO) mice via Ang II infusion, and AF incidence was assessed by e

SUBMITTER: Zeng L 

PROVIDER: S-EPMC12908814 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature