A Whole-body Cooling Strategy in Uncontrolled Donation After Circulatory Death: Insights From a Porcine Ex Vivo Lung Perfusion Model.

ABSTRACT:

Background

Prolonged warm ischemia in uncontrolled donation after circulatory death (uDCD) potentially increases the risk of graft dysfunction in lung transplantation. To address this concern, a noninvasive, whole-body cooling approach was developed using a specialized liquid refrigerant at -21 °C. The aim of this study was to investigate whether this method reduces lung temperature and improves lung function in uDCD donors.

Methods

Fifteen pigs were randomly assigned to 3 groups. In the study group (n = 5), the entire donor body was submerged in a basin containing a coolant of -21 °C, and chest compression was performed during 90 min of warm ischemia. In the sham group (n = 5), neither body cooling nor chest compression was performed during 90 min of warm ischemia. Lungs we

SUBMITTER: Niikawa H 

PROVIDER: S-EPMC12908850 | biostudies-literature | 2026 Mar

REPOSITORIES: biostudies-literature