Sarcopenic Obesity and Cardiovascular Disease Risk and Mortality: A Systematic Review and Meta-Analysis.

ABSTRACT:

Background

While both sarcopenia and obesity independently elevate cardiovascular disease (CVD) risk, their combined effects, known as sarcopenic obesity (SO), remain incompletely understood. This systematic review and meta-analysis aimed to evaluate the association between SO and the risk of CVD and CVD-related mortality.

Methods

A comprehensive search of scientific databases was conducted from inception to May 2025, including observational studies assessing SO in relation to incident CVD or CVD mortality. Pooled odds ratios (ORs) with 95% CIs were calculated using random-effects models. Subgroup analyses examined variations by age, sex, geography, study design, and CVD subtypes, with P-values for interaction being assessed.

Results

Sixteen studies involving 578 408

SUBMITTER: Zhang Z 

PROVIDER: S-EPMC12908878 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature