Phase 1 trial of lavage cytology collected with endoscopic ultrasound-guided fine-needle aspiration for preoperative pancreatic cancer.

ABSTRACT:

Background and study aims

Intraoperative peritoneal lavage cytology (CY) influences prognosis in pancreatic cancer, and positive findings may lead to aborted surgery. Staging laparoscopy is traditionally used when no distant metastases are evident. We developed a novel method to assess CY using endoscopic ultrasound (EUS) and conducted a Phase 1 trial to evaluate its safety.

Patients and methods

This non-randomized, prospective Phase I1trial was conducted in three stages with safety monitoring after each stage. The study was approved by the institutional review board (2023-0-239) and registered (UMIN000052528). Nine patients with pancreatic ductal adenocarcinoma who were considering surgery were enrolled between September 2023 and August 2024. A 3F sheath was inserted into t

SUBMITTER: Okuno N 

PROVIDER: S-EPMC12908912 | biostudies-literature | 2026

REPOSITORIES: biostudies-literature