<i>Helicobacter pylori</i> contributes to GC progression, possibly via the MSTRG.10627.1/miR-142-5p/ADAMTS5 pathway.

ABSTRACT:

Background

Helicobacter pylori (H. pylori) is a class I carcinogen that induces gastric cancer (GC). The mechanisms underlying its induction of GC are not fully understood. The role of the MSTRG.10627.1/miR-142-5p/ADAMTS5 pathway induced by H. pylori in GC was investigated in this study.

Methods

RNA sequencing and bioinformatics analysis were used to screen a regulatory pathway lncRNA-miRNA-mRNA. The dual luciferase reporter was used to evaluate interactions between the lncRNA and the miRNA or between the miRNA and the mRNA. The cellular biological effects of ADAMTS5 were detected using clonogenic formation and cell migration assays. A western blot was used to assess the protein expression of the pathway. The role of ADAMTS5 in tumor growth and metastasi

SUBMITTER: Yin Z 

PROVIDER: S-EPMC12908916 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature