Association of Atrial Electrophysiological Abnormalities With Cognitive Decline and Cerebrovascular Disease.

ABSTRACT:

Background

Atrial electrophysiological abnormalities (AEA) are associated with cognitive dysfunction. We evaluated the associations of AEA with longitudinal cognitive decline and incident dementia and investigated underlying mechanisms.

Methods

In subjects without atrial fibrillation followed prospectively for 5 years, 12-lead ECGs were evaluated for AEA, defined as the presence of sinus node dysfunction (SND), frequent premature atrial complexes, advanced interatrial block (a-IAB), or P-terminal force in V1 (>40 mm*ms). Rate of decline in global cognition (Z-score averaged from 6 cognitive domains), Clinical Dementia Rating-Sum of Boxes score, and associations with cerebrovascular disease on neuroimaging and circulating biomarkers of neurodegenerative disease were de

SUBMITTER: Tan ESJ 

PROVIDER: S-EPMC12908998 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature