Unveiling the Impact of <i>Porphyromonas gingivalis</i>-Associated Periodontitis on Stroke Outcome in Mice.

ABSTRACT:

Background

Periodontitis is a chronic inflammatory condition with infectious origin that affects the tissues supporting the teeth. Increasing epidemiological evidence suggests that periodontitis is a risk factor for ischemic stroke with associated adverse outcomes. However, the underlying mechanism of this association remains incompletely elucidated.

Methods

We used a C57BL/6J mice model of ischemic stroke induced by transitory occlusion of the middle cerebral artery in the presence or absence of ligature-induced periodontitis using Porphyromonas gingivalis-soaked ligatures. Stroke severity was evaluated through infarct volume, sensorimotor deficit, blood-brain barrier (BBB) integrity, and markers of systemic and brain inflammation. The direct effect of P gingivali

SUBMITTER: Diallo D 

PROVIDER: S-EPMC12909060 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature