ATAD2 deficiency leads to subfertility by impairing spermatogenesis in mice.

ABSTRACT: During spermatogenesis, chromatin remodeling regulated by histone modification is essential for spermatogenic cell development, and multiple epigenetic regulators are involved in this process. Recent studies reported that ATAD2 was a newly discovered cancer/testis factor that functioned in chromatin remodeling in somatic cells by binding acetylated histone. However, the physiological role of ATAD2 in spermatogenesis is largely unknown. In this study, we characterized the expression pattern of ATAD2 in mouse testes and found that the highly expressed ATAD2 in the gonads was lowly expressed in meiotic spermatocytes with distinct localization in nucleus, but highly expressed in round spermatids. By generating Atad2 knockout (KO) mice using CRISPR/Cas9 technology, we revealed that ATAD2 deleti

SUBMITTER: Wu R 

PROVIDER: S-EPMC12909092 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature