Assessing racial differences in time to subsequent treatment following androgen deprivation therapy among Veterans with prostate cancer.

ABSTRACT:

Background

For metastatic and certain advanced prostate cancer (PC), guidelines support intensified androgen deprivation therapy (ADT) as first-line (1 L) systemic treatment. However, some patients receive ADT alone, leading to tumor progression requiring 2^nd line therapy. Despite racial disparities in PC outcomes, there are no population-level studies assessing racial differences in time to subsequent treatment after 1 L ADT.

Methods

We performed a retrospective population-level analysis to assess the association between race and time to subsequent treatment after ADT in the Veterans Affairs Health Care System. Primary outcome was time from ADT monotherapy to subsequent treatment, defined as receipt of androgen receptor pathway inhibitor (ARPI), non-steroidal fir

SUBMITTER: Friedrich NA 

PROVIDER: S-EPMC12909120 | biostudies-literature | 2026 Mar

REPOSITORIES: biostudies-literature