Aerobic exercise and MOTS-c attenuate diabetic myocardial fibrosis via inhibition of the THBS1/TGF-β signaling pathway.

ABSTRACT: Myocardial fibrosis stands as a defining pathological characteristic in type 2 diabetes. Aerobic exercise curbs the overproduction of type I/III collagen and boosts matrix metalloproteinases, thereby improving outcomes related to fibrosis in the heart. Although physical activity is well known for its positive effects on cardiac well-being in diabetic individuals, sticking to an exercise regimen proves to be a tough nut to crack for many patients. The mitochondrial peptide MOTS-c could serve as a stand-in for exercise, delivering cardioprotective benefits akin to those from working out. This study delved into the molecular mechanisms behind how exercise and MOTS-c influence cardiac fibrosis in diabetes. Both approaches led to marked enhancements in glucose and lipid metabolism, lowered coll

SUBMITTER: Li Z 

PROVIDER: S-EPMC12909204 | biostudies-literature | 2026

REPOSITORIES: biostudies-literature